Moleküler Biyoloji ve Genetik Seminerleri: Doç. Dr. Stefan H. Fuss

Moleku00fcler Biyoloji ve Genetik Bu00f6lu00fcmu00fcmu00fczu00fcn organize ettiu011fi seminer serisinin yeni konuu011fu, Bou011faziu00e7i u00dcniversitesi’nden Dou00e7. Dr. Stefan H. Fuss olacak.

Dr. Fuss’u0131n u201cTissue regeneration and regulation of neuronal stem cell activity in the adult zebrafish olfactory systemu201d bau015flu0131klu0131 konuu015fmasu0131nu0131 13 Ekim Peru015fembe saat 16:00’dan itibaren Fener Salonuu2019nda dinleyebilirsiniz.

Etkinlik u0130ngilizcedir.u00a0

u00d6zet: The olfactory epithelium is a nervous tissue with an unusually high capacity for cellular self-renewal and repair, which makes it an insightful model to study cellular and molecular mechanisms of post-developmental neurogenesis, tissue regeneration, and the regulation of stem cell activity. Maintenance and regeneration of the zebrafish OE are supported by distinct progenitor cell populations that occupy discrete stem cell niches and respond to different tissue conditions. Globose basal cells (GBCs) are constitutively active under physiological conditions and replace sporadically dying olfactory sensory neurons, while horizontal basal cells (HBCs) are selectively activated by acute injury conditions that affect the morphological integrity of the OE. We are interested in identifying and functionally characterizing molecular signals that selectively activate GBCs and HBCs. We found that GBC activity can be modulated by damage-associated molecular patterns (DAMPS) and undergo increased proliferation when exposed to purine compounds that are released from dying neurons. In contrast, HBCs respond to the heparin-binding epidermal growth factor (HB-EGF), which is highly upregulated in the injured tissue and signals through the EGF receptor to stimulate stem cell expansion and olfactory sensory neurogenesis to support tissue regeneration.

Konuu015fmacu0131 Hakku0131nda:u00a0

BSc: 1996, Johannes-Gutenberg Universitu00e4t, Mainz, Germany (Biology)

MSc: 1997, Johannes-Gutenberg Universitu00e4t, Mainz, Germany (Neuroscience)

PhD: 2002, Universitu00e4t zu Ku00f6ln, Germany (Genetics)

Postdoc: 2002-2006, The Rockefeller University, New York, USA (Neurogenetics)

Asst. Prof.: 2006-2017, Bogazici University, Istanbul, Turkey

Assoc. Prof.: 2017-ongoing, Bogazici University, Istanbul, Turkey

General Secretary: 2018-ongoing, European Chemoreception Research Organization (ECRO)