KEMAL YELEKÇİ

Prof. Dr. KEMAL YELEKÇİ

D BLOK 1. KAT 219

+90 (212) 5336532 - 1332

yelekci@khas.edu.tr

CV

http://www.kemalyelekci.com

ORCID

Eğitim

Doktora

OHİO UNIVERSITY
Organik Kimya

Yüksek Lisans

ÇUKUROVA ÜNİVERSİTESİ
Organik Kimya

Lisans

ORTA DOĞU TEKNİK ÜNİVERSİTESİ
Fen Edebiyat Fakültesi Kimya Bölümü

Araştırma Alanları

  • Bilgisayar Destekli İlaç Tasarımı
  • Moleküler Dinamik Simülasyon ve Doklama
  • Moleküler Modelleme ve Sanal İlaç Taraması
  • Sentetik Organik Kimya
  • Medisinal Kimya

İş Deneyimi

2001 / Devam Eden Prof. Dr.
Kadir Has Üniversitesi, Moleküler Biyoloji ve Genetik

1990 / 2001 Prof. Dr., Doç. Dr.
Marmara Üniversitesi, Kimya Bölümü

1988 / 1989 Yrd. Doç. Dr.
Ege Üniversitesi, Kimya Bölümü

1987 / 1988 Doktora sonrası araştırmacı
Northwestern Üniversitesi, Medisinal Kimya Bölümü

Yayınlar

  • Erensoy, Gizem; Ding, Kai; Zhan, Chang Guo; Çiftçi, Gamze; Yelekçi, Kemal; Duracık, Merve; Bingöl Özakpınar, Özlem; Aydemir, Esra; Yılmaz, Zübeyde Nur; Şahin, Fikrettin; Kulabaş, Necla; Tatar, Esra; Küçükgüzel, İlkay (2023), "Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1", Journal of Molecular Structure, Vol.1272, DOI: 10.1016/j.molstruc.2022.134154
  • Yelekçi, Kemal; Erdem, Safiye Sağ (2023), "Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors", Methods in Molecular Biology, Humana Press
  • Gökoğlan, Ecem; Dere, Damla; Bedir, İpek; Yelekçi, Kemal; Telci, Dilek; Küçükgüzel, Güniz (2023), "Synthesis and investigation of cytotoxic effects of compounds derived from flurbiprofen", Journal of Molecular Structure, Vol.1289, DOI: 10.1016/j.molstruc.2023.135876
  • Shirzad, Mohammad Musa; Kulabaş, Necla; Erdoğan, Ömer; Çevik, Özge; Dere, Damla; Yelekçi, Kemal; Danış, Özkan; Küçükgüzel, İlkay (2023), "Novel azole-urea hybrids as VEGFR-2 inhibitors: Synthesis, in vitro antiproliferative evaluation and in silico studies", Journal of Molecular Structure, Vol.1294, DOI: 10.1016/j.molstruc.2023.136448
  • Birgül, Kaan; Uba, Abdullah Ibrahim; Çuhadar, Ozan; Sevinç, Sevgi Koçyiğit; Tiryaki, Selen; Tiber, Pınar Mega; Orun, Oya; Telci, Dilek; Yılmaz, Özgür; Yelekçi, Kemal; Güniz Küçükgüzel, (2022), "Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents", Journal of Molecular Structure, Vol.1259, DOI: 10.1016/j.molstruc.2022.132739
  • Babandi, Abba; Anosike, Chioma A.; Ezeanyika, Lawrence U.S.; Yelekçi, Kemal; Uba, Abdullahi Ibrahim (2022), "Molecular modeling studies of some phytoligands from Ficus sycomorus fraction as potential inhibitors of cytochrome CYP6P3 enzyme of Anopheles coluzzii", Jordan Journal of Pharmaceutical Sciences, Vol.15, No.2, 258-275
  • Albayati, Safana; Uba, Abdullahi Ibrahim; Yelekçi, Kemal (2022), "Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling", Molecular Diversity, Vol.26, No.2, 1005-1016 DOI: 10.1007/s11030-021-10221-7
  • Boumezber, Sarah; Yelekçi, Kemal (2022), "Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques", Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2022.2054471
  • Demirbolat, İlker; Kulabaş, Necla; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Çiftçi, Gamze; Yelekçi, Kemal; Liu, Jianyang; Jakobsson, Per Johan; Danış, Özkan; Ogan, Ayşe; Küçükgüze, İlkay (2022), "Synthesis and evaluation of antiproliferative and mPGES-1 inhibitory activities of novel carvacrol-triazole conjugates", Organic Communications, Vol.15, No.4, 356-377 DOI: 10.25135/acg.oc.142.2212.2651
  • Cetin, M. Mustafa; Peng, Wenjing; Unruh, Daniel; Mayer, Michael F.; Mechref, Yehia; Yelekci, Kemal (2022), "Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs", Frontiers in Pharmacology, Vol.13, DOI: 10.3389/fphar.2022.980479
  • Bülbül, Bahadır; Ding, Kai; Zhan, Chang Guo; Çiftçi, Gamze; Yelekçi, Kemal; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Aydemir, Esra; Baybağ, Deniz; Şahin, Fikrettin; Kulabaş, Necla; Helvacıoğlu, Sinem; Charehsaz, Mohammad; Tatar, Esra; Özbey, Süheyla; Küçükgüzel, İlkay (2022), "Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity", Molecular Diversity, DOI: 10.1007/s11030-022-10551-0
  • Elmezayen, Ammar D.; Al-Obaidi, Anas; Yelekçi, Kemal (2021), "Discovery of novel isoform-selective histone deacetylases 5 and 9 inhibitors through combined ligand-based pharmacophore modeling, molecular mocking, and molecular dynamics simulations for cancer treatment", Journal of Molecular Graphics and Modelling, Vol.106, DOI: 10.1016/j.jmgm.2021.107937
  • Elmezayen, Ammar D.; Kemal, Yelekçi (2021), "Structure-based virtual screening for novel potential selective inhibitors of class IIa histone deacetylases for cancer treatment", Computational Biology and Chemistry, Vol.92, DOI: 10.1016/j.compbiolchem.2021.107491
  • Salgin-Goksen, Umut; Telli, Gokcen; Erikci, Acelya; Dedecengiz, Ezgi; Tel, Banu Cahide; Kaynak, F. Betul; Yelekci, Kemal; Ucar, Gulberk; Gokhan-Kelekci, Nesrin (2021), "New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors", Journal of Medicinal Chemistry, Vol.64, No.4, 1989-2009 DOI: 10.1021/acs.jmedchem.0c01504
  • Al-Obaidi, Anas; Elmezayen, Ammar D.; Yelekçi, Kemal (2021), "Homology modeling of human GABA-AT and devise some novel and potent inhibitors via computer-aided drug design techniques", Journal of Biomolecular Structure and Dynamics, Vol.39, No.11, 4100-4110 DOI: 10.1080/07391102.2020.1774417
  • Elmezayen, Ammar D.; Yelekçi, Kemal (2021), "Homology modeling and in silico design of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes", Journal of Biomolecular Structure and Dynamics, Vol.39, No.17, 6396-6414 DOI: 10.1080/07391102.2020.1798812
  • Birgül, Kaan; Yıldırım, Yeliz; Karasulu, H. Yeşim; Karasulu, Ercüment; Uba, Abdullah Ibrahim; Yelekçi, Kemal; Bekçi, Hatice; Cumaoğlu, Ahmet; Kabasakal, Levent; Yılmaz, Özgür; Küçükgüzel, Güniz (2020), "Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives", European Journal of Medicinal Chemistry, Vol.208, DOI: 10.1016/j.ejmech.2020.112841
  • Uba, Abdullahi Ibrahim; Yelekçi, Kemal (2020), "Crystallographic structure versus homology model: a case study of molecular dynamics simulation of human and zebrafish histone deacetylase 10", Journal of Biomolecular Structure and Dynamics, Vol.38, No.15, 4397-4406 DOI: 10.1080/07391102.2019.1691658
  • Weako, Jackson; Uba, Abdullahi Ibrahim; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal (2020), "Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies", Computational Biology and Chemistry, Vol.86, DOI: 10.1016/j.compbiolchem.2020.107244
  • Yılmaz, Özgür; Bayer, Burak; Bekçi, Hatice; Uba, Abdullahi I.; Cumaoğlu, Ahmet; Yelekçi, Kemal; Güniz Küçükgüzel, (2020), "Synthesis, anticancer activity on prostate cancer cell lines and molecular modeling studies of flurbiprofen-thioether derivatives as potential target of metap (Type ii)", Medicinal Chemistry, Vol.16, No.6, 735-749 DOI: 10.2174/1573406415666190613162322
  • Erensoy, Gizem; Ding, Kai; Zhan, Chang Guo; Elmezayen, Ammar; Yelekçi, Kemal; Duracik, Merve; Bingöl Özakpinar, Özlem; Küçükgüzel, İlkay (2020), "Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors", Journal of Research in Pharmacy, Vol.24, No.4, 436-451 DOI: 10.35333/jrp.2020.187
  • Elmezayen, Ammar D.; Al-Obaidi, Anas; Şahin, Alp Tegin; Yelekçi, Kemal (2020), "Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes", Journal of Biomolecular Structure and Dynamics, 1-13 DOI: 10.1080/07391102.2020.1758791
  • Samorlu, Augustine S.; Yelekçi, Kemal; Ibrahim Uba, Abdullahi (2019), "The design of potent HIV-1 integrase inhibitors by a combined approach of structure-based virtual screening and molecular dynamics simulation", Journal of Biomolecular Structure and Dynamics, Vol.37, No.17, 4644-4650 DOI: 10.1080/07391102.2018.1557559
  • Ibrahim Uba, Abdullahi; Yelekçi, Kemal (2019), "Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors", Journal of Biomolecular Structure and Dynamics, Vol.37, No.14, 3627-3636 DOI: 10.1080/07391102.2018.1521747
  • Han, Muhammed; Bekçi, Hatice; Uba, Abdullahi I.; Yıldırım, Yeliz; Karasulu, Ercüment; Cumaoğlu, Ahmet; Karasulu, Hatice Y.; Yelekçi, Kemal; Yılmaz, Özgür; Küçükgüzel, Güniz (2019), "Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4-triazole containing hydrazide–hydrazones derived from (S)-naproxen", Archiv der Pharmazie, Vol.352, No.6, DOI: 10.1002/ardp.201800365
  • Djikic, Teodora; Martí, Yasmina; Spyrakis, Francesca; Lau, Thorsten; Benedetti, Paolo; Davey, Gavin; Schloss, Patrick; Yelekci, Kemal (2019), "Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities", Journal of Biomolecular Structure and Dynamics, Vol.37, No.2, 291-306 DOI: 10.1080/07391102.2018.1426044
  • Coşkun, Göknil Pelin; Djikic, Teodora; Kalaycı, Sadık; Yelekçi, Kemal; Şahin, Fikrettin; Güniz Küçükgüzel, (2019), "Synthesis, molecular modelling and antibacterial activity against helicobacter pylori of novel diflunisal derivatives as urease enzyme inhibitors", Letters in Drug Design and Discovery, Vol.16, No.4, 392-400 DOI: 10.2174/1570180815666180627130208
  • Uba, Abdullahi Ibrahim; Weako, Jackson; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal (2019), "Examining the stability of binding modes of the co-crystallized inhibitors of human HDAC8 by molecular dynamics simulation", Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2019.1615989
  • Goksen, Umut Salgin; Sarigul, Sevgi; Bultinck, Patrick; Herrebout, Wouter; Dogan, Ilknur; Yelekci, Kemal; Ucar, Gulberk; Gokhan Kelekci, Nesrin (2019), "Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity", Chirality, Vol.31, No.1, 21-33 DOI: 10.1002/chir.23027
  • Uba, Abdullahi Ibrahim; Yelekçi, Kemal (2018), "Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6", Computational Biology and Chemistry, Vol.77, 318-330 DOI: 10.1016/j.compbiolchem.2018.10.016
  • Uba, Abdullahi Ibrahim; Yelekçi, Kemal (2018), "Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: A combined approach of structure-based virtual screening, admet prediction and molecular dynamics simulation assay", Journal of Biomolecular Structure and Dynamics, Vol.36, No.12, 3231-3245 DOI: 10.1080/07391102.2017.1384402
  • Uba, Abdullahi Ibrahim; Yelekçi, Kemal (2018), "Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies", Computational Biology and Chemistry, Vol.75, 131-142 DOI: 10.1016/j.compbiolchem.2018.05.004
  • Çoruh, Işıl; Çevik, Özge; Yelekçi, Kemal; Djikic, Teodora; Küçükgüzel, Güniz (2018), "Synthesis, anticancer activity, and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors", Archiv der Pharmazie, Vol.351, No.3-4, DOI: 10.1002/ardp.201700195
  • Evranos-Aksöz, Begüm; Uçar, Gülberk; Yelekçi, Kemal (2018), "Investigation of synthesis, molecular modelling and monoaminoxidase inhibitor activity of a new 2-pyrazoline compound", Turk Hijyen ve Deneysel Biyoloji Dergisi, Vol.75, No.3, 253-264 DOI: 10.5505/TurkHijyen.2018.59219
  • Coşkun, Göknil Pelin; Djikic, Teodora; Hayal, Taha Bartu; Türkel, Nezaket; Yelekçi, Kemal; Şahin, Fikrettin; Küçükgüzel, Güniz (2018), "Synthesis, molecular docking and anticancer activity of diflunisal derivatives as cyclooxygenase enzyme inhibitors", Molecules, Vol.23, No.8, DOI: 10.3390/molecules23081969
  • Evranos-Aksoz, Begum; Ucar, Gulberk; Yelekci, Kemal (2017), "Design, Synthesis and hMAO Inhibitory Screening of Novel 2-Pyrazoline Analogues", Combinatorial Chemistry and High Throughput Screening, Vol.20, No.6, 510-521 DOI: 10.2174/1386207320666170504114208
  • Karadeniz, S. T.; Akgul, S. U.; Ogret, Y.; Ciftci, H. S.; Bayraktar, A.; Bakkaloglu, H.; Caliskan, Y.; Yelekci, K.; Turkmen, A.; Aydin, A. E.; Oguz, F. S.; Carin, M.; Aydin, F. (2017), "Corrected Panel-Reactive Antibody Positivity Rates for Hypersensitized Patients in Turkish Population With Calculated Panel-Reactive Antibody Software", Transplantation Proceedings, Vol.49, No.3, 445-447 DOI: 10.1016/j.transproceed.2017.01.032
  • Uba, Abdullahi İbrahim; Yelekçi, Kemal (2017), "Exploration of the binding pocket of histone deacetylases: The design of potent and isoform-selective inhibitors", Turkish Journal of Biology, Vol.41, No.6, 901-918 DOI: 10.3906/biy-1701-26
  • Evranos-Aksoz, Begum; Ucar, Gulberk; Tas, Sadik Taskin; Aksoz, Erkan; Yelekci, Kemal; Erikci, Acelya; Sara, Yildirim; Iskit, Alper Bektas (2017), "New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity", Combinatorial chemistry & high throughput screening, Vol.20, No.6, 461-473 DOI: 10.2174/1386207320666170504113158
  • Nikolic, Katarina; Mavridis, Lazaros; Djikic, Teodora; Vucicevic, Jelica; Agbaba, Danica; Yelekci, Kemal; Mitchell, John B.O. (2016), "Drug design for CNS diseases: Polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies", Frontiers in Neuroscience, Vol.10, No.JUN, DOI: 10.3389/fnins.2016.00265
  • Evranos-Aksöz, Begüm; Baysal, Ipek; Yabanoʇlu-Çiftçi, Samiye; Djikic, Teodora; Yelekçi, Kemal; Uçar, Gülberk; Ertan, Rahmiye (2015), "Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives", Archiv der Pharmazie, Vol.348, No.10, 743-756 DOI: 10.1002/ardp.201500212
  • Malcomson, Thomas; Yelekci, Kemal; Borrello, Maria Teresa; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R. (2015), "Cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases", FEBS Journal, Vol.282, No.16, 3190-3198 DOI: 10.1111/febs.13260
  • Turkmenoglu, Fatma Pinar; Baysal, Ipek; Ciftci-Yabanoglu, Samiye; Yelekci, Kemal; Temel, Hamdi; Paşa, Salih; Ezer, Nurten; Çaliş, Ihsan; Ucar, Gulberk (2015), "Flavonoids from sideritis species: Human monoamine oxidase (hMAO) inhibitory activities, molecular docking studies and crystal structure of xanthomicrol", Molecules, Vol.20, No.5, 7454-7473 DOI: 10.3390/molecules20057454
  • Evranos-Aksöz, Begüm; Yabanoǧlu-Çiftçi, Samiye; Uçar, Gülberk; Yelekçi, Kemal; Ertan, Rahmiye (2014), "Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies", Bioorganic and Medicinal Chemistry Letters, Vol.24, No.15, 3278-3284 DOI: 10.1016/j.bmcl.2014.06.015
  • Eŝiyok, Peruze Ayhan; Seven, Ozlem; Eymur, Gülüzar; Tatar, Gamze Bora; Erden, Didem Dayangaç; Yelekçi, Kemal; Yurter, Hayat; Demir, Ayhan Sitki (2014), "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: Synthesis, in vitro evaluation, and molecular docking studies", Turkish Journal of Chemistry, Vol.38, No.2, 338-344 DOI: 10.3906/kim-1305-56
  • Yelekçi, Kemal; Büyüktürk, Bora; Kayrak, Nurdan (2013), "In silico identification of novel and selective monoamine oxidase B inhibitors", Journal of Neural Transmission, Vol.120, No.6, 853-858 DOI: 10.1007/s00702-012-0954-0
  • Salgin-Gökşen, Umut; Yabanoǧlu-Çiftçi, Samiye; Ercan, Ayşe; Yelekçi, Kemal; Uçar, Gülberk; Gökhan-Kelekçi, Nesrin (2013), "Evaluation of selective human MAO inhibitory activities of some novel pyrazoline derivatives", Journal of Neural Transmission, Vol.120, No.6, 863-873 DOI: 10.1007/s00702-013-0980-6
  • Salgin-Gökşen, Umut; Gökhan-Kelekçi, Nesrin; Yabanoglu-Çiftci, Samiye; Yelekçi, Kemal; Uçar, Gülberk (2013), "Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives", Journal of Neural Transmission, Vol.120, No.6, 883-891 DOI: 10.1007/s00702-013-0968-2
  • Erdem, Safiye Saǧ; Türkkan, Seyhan; Yelekçi, Kemal; Gökhan-Kelekçi, Nesrin (2013), "Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: Docking and quantum chemical calculations", Journal of Neural Transmission, Vol.120, No.6, 859-862 DOI: 10.1007/s00702-012-0950-4
  • Bora Tatar, Gamze; Tokluman, Tenzile Deniz; Yelekçi, Kemal; Yurter, Hayat (2011), "Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design", Turkish Journal of Chemistry, Vol.35, No.6, 861-870 DOI: 10.3906/kim-1107-34
  • Akdoǧan, Ebru Demet; Erman, Burak; Yelekçi, Kemal (2011), "In silico design of novel and highly selective lysine-specific Histone demethylase inhibitors", Turkish Journal of Chemistry, Vol.35, No.4, 523-542 DOI: 10.3906/kim-1102-985
  • Gökhan-Kelekçi, Nesrin; Şimşek, Ö Özgün; Ercan, Ayşe; Yelekçi, Kemal; Şahin, Z. Sibel; Işik, Şamil; Uçar, Gülberk; Bilgin, A. Altan (2009), "Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors", Bioorganic and Medicinal Chemistry, Vol.17, No.18, 6761-6772 DOI: 10.1016/j.bmc.2009.07.033
  • Bora-Tatar, Gamze; Dayangaç-Erden, Didem; Demir, Ayhan S.; Dalkara, Sevim; Yelekçi, Kemal; Erdem-Yurter, Hayat (2009), "Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies", Bioorganic and Medicinal Chemistry, Vol.17, No.14, 5219-5228 DOI: 10.1016/j.bmc.2009.05.042
  • Dayangaç-Erden, Didem; Bora, Gamze; Ayhan, Peruze; Kocaefe, Çetin; Dalkara, Sevim; Yelekçi, Kemal; Demir, Ayhan S.; Erdem-Yurter, Hayat (2009), "Histone deacetylase inhibition activity and molecular docking of (e)-resveratrol: Its therapeutic potential in spinal muscular atrophy", Chemical Biology and Drug Design, Vol.73, No.3, 355-364 DOI: 10.1111/j.1747-0285.2009.00781.x
  • Gökhan-Kelekçi, Nesrin; Koyunoǧlu, Semra; Yabanoǧlu, Samiye; Yelekçi, Kemal; Özgen, Özen; Uçar, Gülberk; Erol, Kevser; Kendi, Engin; Yeşilada, Akgül (2009), "New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity", Bioorganic and Medicinal Chemistry, Vol.17, No.2, 675-689 DOI: 10.1016/j.bmc.2008.11.068
  • Erdem, Safiye Saǧ; Uyar, Fahriye; Karahan, Özlem; Yelekçi, Kemal (2007), "Thermal rearrangement of 2-acetoxy-2,6,6-trimethylbicyclo[3.1.0]hexane: Theoretical elucidation of the mechanism", Journal of Molecular Structure: THEOCHEM, Vol.814, No.1-3, 61-73 DOI: 10.1016/j.theochem.2007.02.041
  • Yelekçi, K.; Karahan, Ö; Toprakçi, M. (2007), "Docking of novel reversible monoamine oxidase-B inhibitors: Efficient prediction of ligand binding sites and estimation of inhibitors thermodynamic properties", Journal of Neural Transmission, Vol.114, No.6, 725-732 DOI: 10.1007/s00702-007-0679-7
  • Erdem, Safiye Saǧ; Karahan, Özlem; Yidiz, Ibrahim; Yelekçi, Kemal (2006), "A computational study on the amine-oxidation mechanism of monoamine oxidase: Insight into the polar nucleophilic mechanism", Organic and Biomolecular Chemistry, Vol.4, No.4, 646-658 DOI: 10.1039/b511350d
  • Toprakçí, Mustafa; Yelekçi, Kemal (2005), "Docking studies on monoamine oxidase-B inhibitors: Estimation of inhibition constants (Ki) of a series of experimentally tested compounds", Bioorganic and Medicinal Chemistry Letters, Vol.15, No.20, 4438-4446 DOI: 10.1016/j.bmcl.2005.07.043
  • Erdem, Safiye Saǧ; Yelekçi, Kemal (2001), "Computer modeling of oxygen containing heptylamines as monoamine oxidase inactivators", Journal of Molecular Structure: THEOCHEM, Vol.572, No.1-3, 97-106 DOI: 10.1016/S0166-1280(01)00587-5
  • Yelekçi, Kemal; Silverman, Richard B. (1998), "Effect of the locus of the oxygen atom in amino ethers on the inactivation of monoamine oxidase B", Journal of Enzyme Inhibition, Vol.13, No.1, 31-39 DOI: 10.3109/14756369809035825
  • DeRose, Victoria J.; Woo, Jonathan C.G.; Hawe, William P.; Hoffman, Brian M.; Silverman, Richard B.; Yelekci, Kemal (1996), "Observation of a flavin semiquinone in the resting state of monoamine oxidase B by electron paramagnetic resonance and electron nuclear double resonance spectroscopy", Biochemistry, Vol.35, No.34, 11085-11091 DOI: 10.1021/bi960749f
  • Yelekci, Kemal; Lu, Xingliang; Silverman, Richard B. (1989), "Electron Spin Resonance Studies of Monoamine Oxidase B. First Direct Evidence for a Substrate Radical Intermediate", Journal of the American Chemical Society, Vol.111, No.3, 1138-1140 DOI: 10.1021/ja00185a059
  • Huntsman, William D.; Pin Chen, Jom; Yelekci, Kemal; Yin, Tyze Kuan; Jian Zhang, Li (1988), "Thermal Aromatization of Alkylidenecyclopentenes and Related Hydrocarbons", Journal of Organic Chemistry, Vol.53, No.18, 4357-4363 DOI: 10.1021/jo00253a031

Projeler

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Meme Kanseri Tedavisine Yönelik Yeni Sentetik Ajanların Geliştirilmesi Araştırmacı Ulusal Proje Diğer Ulusal 01.05.2022
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Kanser tedavisinde kullanılmak üzere histon deasetlaz HDAC6 ve HDAC10 enzimlerine karşı in siliko tarama ve medisinal kimya yaklaşımlarını kullanılarak etkili ve seçimli yeni inhibitörle Yürütücü Ulusal Proje Diğer Ulusal 01.03.2020
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COST CM1406 Epigenetik Kimyasal Biyoloji (EPICHEM)/ Epigenetic Chemical Biology (EPICHEM) Yürütücü Uluslararası Proje Diğer Uluslararası 13.11.2014
18.11.2018
FP7-PEOPLE-2013-ITN: Training in Neurodegeneration, Therapeutics Intervention & Neurorepair Yürütücü Uluslararası Proje HORIZON 2020 01.10.2013
30.09.2017
Cost Action CM1103: Structure-based Drug Design for Diagnosis and Treatment of Neurological Diseases: Dissecting and Modulating Complex Function in the Monoaminergic System of the Brain. Yürütücü Uluslararası Proje Diğer Uluslararası 18.03.2013
18.03.2015
211 T100-TBAG: Nörodejenerative Hastalıkların Önlenmesine Yönelik In Silico Nöronal Nitrik Oksit Sentez (nNOS) Seçimli İnhibitör Tasarımı Yürütücü Ulusal Proje TÜBİTAK ARDEB 01.02.2012
01.03.2013
108T232: Monoamin Oksidaz (MAO) Inhibitör Etkili Yeni Pirazolin Türevlerinin Moleküler Modelleme Yöntemiyle Tasarlanması, Sentezi ve Inhibisyon Kinetiklerinin Hesapsal ve Deneysel Olarak Tayi Yürütücü Ulusal Proje TÜBİTAK Diğer 02.02.2008
01.08.2010
Project Reference 30005: MOBILITY-COMPIB-Characterisation of Mitochondrial Proteins in the Brain Yürütücü Uluslararası Proje FP7 01.05.2006
30.04.2010

Verilen Dersler

Ders Adı Ders Kodu Dönem
Biyoorganik Kimya II MBG212 2023/24 Bahar
Yapısal Biyoloji Metodları MBG408 2023/24 Bahar
Biyoorganik Kimya I MBG211 2023/24 Güz
Farmakofor Modelleme MBG319 2023/24 Güz